the function of mutant CFTR proteins in cells. To date, two systemic small-molecule CFTR modulators have been evaluated in pivotal clinical trials in individuals with CF and specific mutant CFTR ...

Incorporating the amino acid building block proline into the nascent protein molecule presents a particular challenge for the cell during protein biosynthesis. Due to its rigid structure ...

This grant recognizes Hartman’s work in developing genetic strategies to restore the function of the CFTR protein, which is defective in individuals with cystic fibrosis. Hartman, a UAB alumnus, ...

It is being investigated in combination with the chemotherapy molecule called doxorubicin ... gene that allows lung cells to make a working CFTR protein and prevention infection.

Protein has become a major focus in the American diet ... According to research published in the International Journal of Molecular Sciences lentils are rich in bioactive compounds that help reduce ...

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[1] These mutations are called gating mutations. The CFTR protein reaches the cell membrane but the channel does not open properly and chloride transport cannot occur (Figure 1d). Class IV ...

"ProteinTok" is everywhere. From Protein Diet Coke to high-protein desserts, it feels like everyone on the internet is talking about one thing: More. Protein. While plenty talk about protein ...

Affecting tens of thousands of people worldwide, CF is caused by a defective or missing CFTR protein. The CFTR discovery generated global excitement as ... to support the less than 10% of patients ...

Scientists at the University of California, Riverside (UCR), have developed a “molecular crowbar” strategy to identify protein degraders that target Pin1, a protein involved in pancreatic ...