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多肽偶联药物(PDC)的结构机制、优势、研发现状与未来展望
PDC中使用的肿瘤归巢肽根据功能主要分为两类:细胞靶向肽(CTPs)和细胞穿透肽(CPPs)。CTPs与肿瘤细胞表面受体结合后,通过受体介导内吞作用将PDC药物运送至细胞内,在溶酶体中连接子被相关酶裂解释放毒素,从而杀伤肿瘤细胞。CTPs与肿瘤细胞表面过表达的 ...
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