该工作系统研究了AsCas12f1及其改进型突变体对靶DNA切割过程的动力学分子机制。研究发现，AsCas12f1解旋原间隔区内DNA后，在非靶链DNA上产生缺口（nick）并进行双向外切模式的核酸降解；随后，AsCas12f1把DNA解旋范围扩展到 ...

In this study, researchers developed a new method combining two advanced technologies, Loop-mediated Isothermal Amplification (LAMP) and CRISPR/Cas12a, to quickly and accurately detect different ...

English等人用RNA引导的Cas12a核酸酶来设靶并裂解水凝胶内的特定（但任意）的由用户定义的DNA部分，从而触发对该材料的驱动。为阐明可编程CRISPR ...

At this time, the core can perform genome editing with S.p. Cas9 or A.s. Cas12a/Cpf1. The targeting will be done in embryos using microinjection to introduce the CRISPR reagents. The investigator will ...