This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in lymphoma development and therapy.

While Cas9 has been the predominant enzyme in CRISPR applications over the past decade, Cas12a offers advantages. “In contrast to Cas9, Cas12a can delete multiple genes at the same time with ...

Conventional CRISPR nucleases, including Cas9 and Cas12a, exceed the packaging limits of a single AAV vector, necessitating ...

As an advocate for the needs of researchers working at the forefronts of genomic research, Integrated DNA Technologies (IDT) releases its latest CRISPR enzyme Alt-R® Cas12a (Cpf1) Ultra. Cas12a Ultra ...

Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, ...

One of the proteins, AcrVA1, emerged as the most effective at countering Cas12a, suggesting it could become another tool to keep CRISPR gene editing in check, the scientists say. “The strategy ...

A team of researchers from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences has developed a point-of-care testing (POCT) system based on microfluidic CRISPR-Dx technology, ...

The researchers were also able to identify genes that led to accelerated lymphoma growth in the pre-clinical model by using unique Cas12a-compatible mouse whole-genome CRISPR "libraries." ...

Additionally, Editas Medicine management will participate in the following upcoming investor conferences in March: To access the live webcasts of Editas Medicine’s presentations, please visit the ...