Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, providing insights into its DNA recognition and cleavage mechanisms.

CRISPR technology, driven by Cas9, redefines gene editing, facilitating targeted DNA modifications that advance genetic ...

Efficient and site-specific genome engineering can be achieved based on programmable nucleic acid cleavage using CRISPR-Cas surveillance complexes. Structure-function studies on single component Cas ...

Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, providing insights into its DNA recognition and cleavage mechanisms.

Dec. 4, 2024 — Researchers have uncovered a serious side effect of using the CRISPR-Cas gene scissors. A molecule designed to make the process more efficient destroys parts of the ...

Learn about our Editorial Policies. We can target harmful bacteria. We can engineer beneficial bacteria. We can use CRISPR to study microbial interactions. We can use CRISPR to remove antibiotic ...

Science 369, 54-59. Topology of the type I CRISPR Cascade complexes and targeting by anti-CRISPR proteins. Guo, T. W. et al., (2017). Cryo-EM structures reveal mechanism and inhibition of DNA ...

CRISPR is a technology that can be used to edit genes and, as such, will likely change the world. The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside a cell.