CRISPR-Cas systems are prokaryotic immune systems that confer resistance to foreign genetic elements such as plasmids and phages. CRISPR-Cas systems have been exploited for targeted genome editing.

CRISPR/Cas systems are widespread RNA-mediated prokaryotic adaptive immune systems providing protection against invading nucleic acids 1. However, throughout evolution, this host defense system ...

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This work is published on bioRxiv in a preprint titled, “Single-AAV CRISPR editing of skeletal muscle in non-human primates with NanoCas, an ultracompact nuclease.” NanoCas is a novel Cas ...

These phenomena raise questions about the ability of artificial device to regulate miRNAs and TFs simultaneously. In this study, we aimed to construct an artificial long non-coding RNA, “alncRNA,” ...

Take CRISPR Therapeutics (NASDAQ: CRSP) and Intellia Therapeutics (NASDAQ: NTLA), two biotechs specializing in gene editing. Finance, is $83.60; the latter earns a price target of $50.80 from ...

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With the recent development of the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system, gene editing has become efficient ... 2017). SITE-seq reduces the background noise of ...

1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198-5900 USA 2Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical ...

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CRISPR-Cas 系统是细菌和古菌的适应性免疫系统，能够抵御病毒和可移动遗传元件的入侵。尽管 CRISPR-Cas9 和 CRISPR-Cas12 系统的 DNA 靶向机制已经被广泛研究，但 RNA 靶向的 CRISPR-Cas13 系统的进化起源，目前仍然不清楚。 2025年2月18日，张锋团队在国际顶尖学术期刊 Cell ...