School of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China ...

结果发现，与体外实验结果不同，R2lc 处理的小鼠前脑内 AhR、Cyp1b1 和 AhRR 基因表达降低，而 R2lcΔpks 处理组的基因表达情况和 PB-W1 处理组相似。这说明 R2lc 通过 pks 基因簇抑制了 AhR 通路基因的表达。 罗伊氏乳杆菌以菌株特异性方式调节紧密连接蛋白基因表达 ...

Birth control pills can result in hair loss as a side effect. However, this is usually temporary. As with any medication, the birth control pill can cause side effects. Some people may find that ...

这项研究揭示了角质形成细胞中 AhR - Ovol1 - Id1 调节轴在维持表皮和免疫稳态中的关键作用。在特应性皮炎样皮肤炎症中，AhR 激活后直接促进 OVOL1 的表达，OVOL1 进而影响 AhR 对基因表达的调控，使角质形成细胞从增殖状态转变为分化状态，增强皮肤屏障功能，并调节免疫反应。Ovol1 通过抑制其下游靶基因 Id1 ...

The dominant rationale to generate new (and to assess old) anticancer chemotherapeutic agents is to determine their cell-autonomous effects — that is, their capacity to reduce the growth ...

George Coukos, MD, PhD, Department of Oncology, University Hospital of Lausanne, Rue du Bugnon 46, Lausanne 1011, Switzerland; e-mail: [email protected]. If you have the appropriate software installed ...

Background: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune central nervous system (CNS) inflammatory and demyelinating disorder that can lead to serious disability and mortality.

School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China Euodiae Fructus (EF) is the dried and nearly ripe fruit of Euodia rutaecarpa, first recorded in Shen Nong’s ...

Our previous findings that arachidonic acid-12/15-lipoxygenase (LOX)-generated metabolite 12(S)-HETE contributes to angiotensin II (AngII)-induced hypertension and 17β-estradiol protects from ...