During tumorigenesis, stromal NOFs may undergo activation into cancer-associated fibroblasts (CAFs) that modify their phenotype to provide pro-oncogenic signals that in turn facilitate tumor ...

Breast cancer cells, when disseminated to other secondary organs such as the lungs, may stay in a dormant state for years, even decades. But the mechanisms that limit their expansion are not well ...

About 80% of people who have lung cancer have non-small-cell lung cancer. NSCLC usually spreads more slowly than small-cell lung cancers. Both cancers affect the lungs and have similar symptoms ...

Malignant cells down-regulate cell death by overexpressing a transcription factor called BCL6. “Our idea was to borrow a little bit of the activity of the kinase and drag it over to where BCL6 is ...

Some of the most widely used drugs today, including penicillin, were discovered through a process called phenotypic screening ...

A low white blood cell count is called leukopenia. A high white blood cell count is usually a sign of inflammation or infection, but it can be due to a blood-related cancer like leukemia or lymphoma.

Estrogens Play a Hidden Role in Cancers, Inhibiting a Key Immune Cell Sep. 27, 2024 — Estrogens are known to drive tumor growth in breast cancer cells that carry its receptors, but a new study ...

On one hand, cancer cells need to lose their chemoprotective ... and a network of genes has been identified that confers a drug resistance phenotype similar to that of mammalian cells 9.

Modifying a protein that controls cell growth can reactivate dormant neural stem cells in fruit flies which could help ...

Cancer growth blockers are also called cancer growth inhibitors. They are a type of targeted cancer drug. Our body makes chemicals called growth factors that control cell growth. Cancer growth ...