Elena Shagisultanova, MD, PhD, is working to uncover effective treatments for HER2-positive breast cancer patients by combining different drugs to counteract the cancer cells’ proliferation.
suggesting a role in NK cell exhaustion. TIPE2, a negative regulator of IL-15 signaling, is upregulated in various conditions and suppresses downstream AKT and Ral activation. The absence of TIPE2 ...
It involves cell proliferation, migration, differentiation ... it can exert neuroprotective effects through GPCR signaling pathways, including regulating the PI3K/Akt and ERK signaling pathways.
Studies have shown that PD inhibits the proliferation of liver cancer cells and induces apoptosis in tumor cells by suppressing Protein kinase B (Akt) phosphorylation (Jiang et al ... with 5-FU ...