Some larger cargo, such as membrane proteins, nutrients, and pathogens, enter the cell via a process known as clathrin-mediated endocytosis. To gain a deeper understanding of this important ...

GPCRs such as the β2ARs also undergo regulated endocytosis that is mediated by agonist concentration in pre-existing clathrin-coated pits 111. β2ARs were found to concentrate uniformly in ...

International Journal of Pharmaceutics May 10; 390(2):198-207, 2010. [3] J. Rejman, A. Bragonzi and M. Conese, Role of clathrin- and caveolae mediated endocytosis in gene transfer mediated by lipo- ...

Yet, those cells lack TMPRSS2, and if a virus–ACE2 complex does not encounter this plasma membrane-associated protease, it is internalized via clathrin-mediated endocytosis into the endolysosomes, ...

The European Molecular Biology Laboratory (EMBL) is Europe's esteemed lab network for research in molecular biology. EMBL is funded by 20 member states an one associate member. EMBL operates in 5 ...

As a consequence, induction of downstream genes by these stimuli is reduced or abrogated. This effect of HCQ is not mediated by direct interference with the agonists but by inhibiting the ...

1 School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China 2 Department of Dermatology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua ...

Centre for Inflammation Research, The University of Edinburgh, EH16 4UU Edinburgh, U.K. IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, EH16 4UU Edinburgh, U.K.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Transient receptor potential vanilloid 1 ...

Canada Post and its workers’ union are entering a fresh round of mediated negotiations as a nationwide postal strike enters its fourth day Both sides return to the bargaining table Monday with a ...

Shenzhen Bay Laboratory, Lab of Computational Chemistry and Drug Design, State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China ...