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生物通
7 分钟
肠道微生物群通过精氨酸代谢影响结直肠癌进展:机制新探与潜在靶点
精氨酸,作为人体生长发育的半必需氨基酸,在 CRC 的发展过程中扮演着复杂的角色。它可以通过多胺合成通路、一氧化氮(NO)合成通路和鸟氨酸循环等途径影响 CRC 进展。精氨酸代谢还能调节肿瘤浸润巨噬细胞的极化,进而影响肿瘤的发展。然而,精氨酸对 CRC 的影响是一把双刃剑,既能促进肿瘤生长,也能抑制肿瘤发生,目前对于是否应给 CRC ...
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