Adenoviral vectors will transduce a wide range of target cells resulting in high-level gene expression. They are non-integrating vectors so expression in dividing cells is progressively lost. First ...

Ad5 vectors are the most commonly used adenovirus vector. Ad5 vectors transduce a wide range of cell types. They utilize the Coxsackie-Adenovirus Receptor (CAR) to enter cells. Transduction efficiency ...

They engineered an adenoviral vector to include a repressor protein (TetR) and its binding site (tetracycline operator, TetO) in the MLP. Adding these two elements means that once the MLP is ...

An inhalable version of a single-shot, adenovirus-based viral vector vaccine might provide a new option for COVID-19 vaccination. In October 2021, the World Health Organization set a target for ...

CONVIDECIA, administered in a single dose, “is based on a modified human adenovirus expressing the S-spike protein of SARS-CoV-2,” the virus that causes COVID-19. The vaccine was found to be ...