近日，复旦大学王永明教授与东南大学柴人杰教授联合团队在Science Bulletin上发表题为“Discovery and engineering of ChCas12b for precise genome ...

This study presents important findings on cold tolerance shared between hibernating and non-hibernating mammals, identifying a key molecule, GPX4, through multi-species genome-wide CRISPR screens. The ...

在细菌和古生物中发现了多种多样的CRISPR-Cas系统，例如基于Cas12或Cas13的系统，它们分别以DNA和RNA为靶向。 研究人员从公共宏基因组和基因组序列中提取的72831个CRISPR-Cas基因座上微调Evo，为Cas9，Cas 12和Cas 13添加特殊的提示token，这些标记被预先添加到每个训练 ...

生成合成CRISPR-Cas分子复合物和转座子系统的结果表明，Evo在多模态生成任务上的表现也很出色。 此外，研究人员还首次使用语言模型，进行了蛋白 ...

CRISPR-Cas基因编辑技术在基础研究 ... Cas蛋白作为该系统的核心组件，除了广为人知的II型Cas9蛋白外，V型Cas12家族（如Cas12a至Cas12n）也逐渐被发掘。

Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area Delle Scienze 17/A, 43124 Parma, Italy ...

Table 1. DA sample recovery. As part of our ongoing effort to innovate scientific research, we have effectively created a novel approach to dopamine (DA) detection using the CRISPR/Cas12 gene editing ...

A pipeline for the analysis of CRISPR edited data. It allows the evaluation of the quality of gene editing experiments using targeted next generation sequencing (NGS) data (`targeted`) as well as the ...

"Unlike the well-known CRISPR gene-editing system, often described as molecular 'scissors,' the newly studied type IV-A CRISPR system does not cut genes. Instead, it uses an RNA-guided 'effector ...