Many genetic variants in drug metabolizing enzymes and transporters have been shown to be relevant for treating psychiatric disorders. Associations are strong enough to feature on drug labels and for ...

Korah leads a rebellion against Moses and Aaron; plague sent by God; Aaron’s rod; duties for priests; the tithe offering Korah, Dathan, and Abiram rose up before Moses, with certain of the children of ...

Background: Matrine, an alkaloid derived from the dried roots of Sophora flavescens Aiton, has been utilized for the treatment of liver diseases, but its potential hepatotoxicity raises concerns.

Diabetes. 2005;54(6):1615-1625. The polyol pathway, shown schematically in Fig. 2, focuses on the enzyme aldose reductase. Aldose reductase normally has the function of reducing toxic aldehydes in ...

As was seen in the case of LDL-C, clinical success may be dependent on the biological pathway by which the biomarker is manipulated. This is exemplified through clinical experience contrasting drugs ...

To discover that there is uncertainty about the sex of one’s newborn baby is devastating and often incomprehensible for most parents. It is paramount that clear explanations and investigations are ...

Oral protein kinase Cβ2/1 inhibitor, ruboxistaurin. - More effective aldose reductase inhibitors. Benfothiamine. Inhibitors of leukostasis, such as anti-inflammatory agents. Use of hyaluronidase ...