Medivir has developed MIV-818, a prodrug which is cleaved inside the tumor cells to produce the active metabolite TRX-TP. Subsequently, TRX-TP is incorporated into DNA, causing double-strand DNA ...

Its effect is based on the breaking of the disulfide bridges of mucus glycoproteins ... With these two blocked thiol groups, erdosteine is an inactive prodrug. Erdosteine is stable only in ...