More than 1,000 different drugs are thought to cause liver damage and one French study estimated the global annual incidence rate of drug-related liver damage as 8 cases per 100,000 inhabitants ...
Drug-induced liver injury (DILI) is common because it can be caused by different pharmacological agents from nearly all classes of medications, including hepatotoxic drugs, anesthetics, anticancer ...
Derisking of drug-induced liver injury (DILI) continues to be a challenge for pharmaceutical scientists. Join Michael Hafey, Principal Scientist at Merck, as he discusses how to utilize a two-tiered ...
Drug-induced liver injury including cholestasis is another form of acquired liver disease, accounting for approximately 2 to 5% of hospitalizations for jaundice, 10% of cases of hepatitis in all ...
The drugs' cytotoxicity correlated well with all three types of classification reported in the DILIrank dataset, an FDA resource: DILIconcern class, liver injury description, and hepatotoxicity ...