Northwestern University researchers have identified structural features in engineered cell receptors that correlate with ...

Shedding of the ectodomain (soluble extracellular part of the protein) of GPI-anchored proteins has been described as an important post-translational mechanism involved in adhesion and cell signaling ...

Using protein structure prediction tools, researchers have uncovered receptor structure-function relationships to improve cell therapies.

Natural killer (NK) cells are the predominant innate lymphocyte subsets that mediate anti-tumor and anti-viral responses, and therefore possess promising clinical utilization. NK cells do not express ...

论文的摘要指出，整合应激反应（Integrated Stress Response，ISR）是细胞应对各种压力、恢复体内平衡的重要信号网络。当细胞无法恢复平衡时，ISR 会促使细胞死亡，清除受损严重的细胞。以往研究表明，在内质网（Endoplasmic Reticulum，ER）持续应激时，ISR 激酶 PERK 的持续激活会诱导死亡受体 5（Death Receptor ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Non-Commercial (NC): Only non-commercial uses of the work are permitted. No ...

为解决 cPcdhs 在神经元布线中作用机制不明的问题，上海交通大学医学院的研究人员开展 cPcdh-γB4 原位组装研究。结果发现胞外和胞内结构域共同调节其组装。该研究为理解神经元发育提供关键线索，值得科研人员一读。