A common property of signalling receptor endocytosis is the efficient sorting of receptors for lysosomal degradation, which is mediated by their ubiquitylation and sorting into intraluminal ...

Among these sensors, we further focused on the spatiotemporal dynamics of Rab10 and Rab4 activity during sLTP. We found that postsynaptic stimulation leads to the persistent inactivation of Rab10 and ...

A decade after the discovery of CALR, the results are the first for a possible therapy for CALR-mutated MPNs to reach the ...

Some larger cargo, such as membrane proteins, nutrients, and pathogens, enter the cell via a process known as clathrin-mediated endocytosis. To gain a deeper understanding of this important ...

Dr. Reddy's Laboratories launches Toripalimab in India, a groundbreaking treatment for metastatic and recurrent ...

Toripalimab is an anti-PD-1 monoclonal antibody that can block PD-1 interactions with its ligands, PD-L1 and PD-L2, and for ...

新冠肺炎疫情危害全球，各界都想进一步了解病毒如何感染？国立成功大学微生物及免疫学研究所副教授凌斌团队歷经长达10年的研究，发现病毒侵入细胞后最早的人体防御机制启动新模式，比过去的理解至少提前半天或数小时，未来不仅可做为开发新型疫苗的参考，对红斑性狼疮 ...

Daniel joined The EMBO Journal in 2015. Ieva received her PhD from the University of Göttingen where she worked on cell polarity and endocytosis in Drosophila in the lab of Andreas Wodarz. In 2011 she ...

Dr. Reddy's Laboratories Ltd. (BSE: 500124, NSE: DRREDDY, NYSE: RDY, NSEIFSC: DRREDDY; along with its subsidiaries together ...

We have observed that anti-TNF antibodies bind to transmembrane TNF (tmTNF) and undergo endocytosis to the lysosome (1). We have developed a stable antibody drug conjugate (ADC), ABBV-3373, that has a ...