The determined kinetic parameters also suggest that only a small part of total OADH synthesized in the liver contributes to the overall complex-catalyzed reaction of oxidative decarboxylation of OA.

By combining enzyme kinetics, biophysics, structural biology, and transgenic parasite survival assays, we provide a proof-of-principle that the sdAb-mediated enzyme inhibition negatively impacts ...

Binding to the T-state of the enzyme is further supported by non-linear inhibition kinetics. PYK is an important enzyme in the glycolytic pathway, and inhibition is likely to have an impact on ...

Angiotensin-converting enzyme (ACE) inhibitors are oral medications that lower blood pressure. They are used to treat a variety of heart-related conditions including high blood pressure, coronary ...

The results presented here indicate that specific, potent inhibitors of the hTERT enzyme are likely to be very effective in limiting the growth of many types of human cancer cells.

We constructed a ZIKVpro expressing vector containing NS2B (residues 45–96) and NS3pro (residues 1-177) linked by a (Gly) 4-Ser-(Gly) 4 sequence, followed by a poly-histidine tag in C-terminal ends, ...

(12) Here, we systematically survey and compare the structural mechanism of ligands bound to helicases in the Protein Data Bank (PDB) to gain insight into the structural chemistry of enzyme inhibition ...

In collaborative work, Trethera and the Peter Clark Lab at UCLA have shown that when autoreactive T and B cells divide, they ...

The enzyme aconitate decarboxylase 1 (Acod1 ... Single cell energetic metabolism by profiling translation inhibition Cells isolated from ankle tissue were resuspended in HBSS and stimulated either ...

We show that one such compound, canagliflozin (Invokana), a type-2 diabetes drug already in clinical use, can strongly delay the kinetics of IAPP amyloid formation, an activity independent of its ...

Cell escape was evaluated using the techniques established by Maniyam and coauthors [15]. Various models are employed to describe the biodegradation of organic pollutants, with the first-order kinetic ...