This important study examines the role of pericytes in patterning the zebrafish blood-brain barrier (BBB) and controlling its permeability. Using pdgfrb mutant zebrafish models lacking brain pericytes ...

The glucoregulatory functions of pancreatic islets are affected by their surrounding niche and spatial organization. Here, bioengineered stem-cell derived islet niches use bioprinting-based ...

This is an important and solid study that examines the role of TFAM, a protein that helps maintain mtDNA, in mtDNA mutator mice. The authors have demonstrated that TFAM's counteractive role in mtDNA ...

Connective tissue diseases are a heterogeneous group of autoimmune disorders that affect any of the body's connective tissues. These disorders can be inherited or acquired, and can present with a ...

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-5127, United States ...