G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

In general, understanding these dynamics can provide insight into potential therapeutic targets and aid in drug discovery for these patients. In addition to GPR84, another G protein-coupled receptor ...

A basic function of cells is that they act in response to their environments. It makes sense, then, that a goal of scientists ...

A team of scientists led by Professor Annette Beck-Sickinger from the Institute of Biochemistry at Leipzig University has ...

University of Southern California-led researchers have discovered the structural details of a brain receptor called GPR6, ...

Receptors are cellular components that trigger internal changes based on external signals. Researchers have built a new synthetic receptor with incredibly broad potential to program cell activity, ...

Researchers have identified a natural substance, hederagenin, that blocks the NPFFR1 receptor, a protein involved in pain perception in the brain and spinal cord.

GPR6, a G protein-coupled receptor, is primarily expressed in the medium spiny neurons of the striatum, specifically within ...

Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, Canada Department of Computer Science, University of Toronto, Toronto, ON M5S 3E1, Canada Department ...