G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

While treating chronic pain with opioids is still challenging thanks to the risk of severe side effects as well as dependency ...

Protwis is the backbone of the GPCRdb. The GPCRdb contains reference data, interactive visualisation and experiment design tools for G protein-coupled receptors (GPCRs).

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Chemokines are a subclass of ...

This project presents integrated experimental and computational studies of mechanisms of recognition of novel small-molecule based therapeutics for targeting allosteric sites in intracellular ...

An estimated one in five Americans live with chronic pain and current treatment options leave much to be desired. Feixiong ...

G protein-gated ion channels are a family of transmembrane ion channels in neurons and atrial myocytes that are directly gated by G proteins. Generalized diagram of G protein-gated ion channel: (A) ...

The artificial intelligence algorithm recognized multiple gut metabolites and FDA-approved drugs that have the potential to ...