Imprinting is yet another process involved in eukaryotic gene regulation; this process involves the silencing of one of the two alleles of a gene for a cell's entire life span. Imprinting affects ...

The role of RNA in information transfer and catalysis highlights its dual functionalities. Our laboratory has a long-standing interest in RNA folding, recognition, and catalysis. We are especially ...

Using silencer-seq, the Stark lab identified 800+ silencers and the transcription factor Saft in fruit flies, enhancing our ...

Controlling gene expression is essential to growth, development, and sustained life. This requires regulating the spacial, temporal, and developmental expression of genes in a wide diversity of cell ...

Transcriptional regulation in organelles is mostly used for global rather than subtle changes in gene expression. Anterograde control of organelle gene expression is primarily post-transcriptional ...

Some sequences in the genome cause genes to be switched on or off. Until now, each of these gene switches, or so-called enhancers, was thought to have its own place on the DNA. Different enhancers ...

The course explores gene regulation in eukaryotes from nuclear organisation to cytosolic control, with a focus on animals and humans. The molecular mechanisms of transcription within a chromatin ...

Gene expression determines the phenotype of cells and tissues, making the regulation of gene expression fundamental to nearly all physiological processes, in both health and disease. Environmental ...

Along our journey, we shall reveal basic principles of gene regulation. We aim to exploit the new knowledge to help devise novel treatments of many diseases that stem from misregulated gene ...

Depending on how much and which part of the region is modified, different areas of the pigment pattern change. This shows ...

This study presents important findings on the role of CXXC-finger protein 1 in regulatory T cell gene regulation and function. The evidence supporting the authors' claims is solid, with mostly ...

Scientists have finally uncovered the genetic mutation responsible for the orange coloration in domestic cats, solving a ...