Aging depletes the brain’s protective sugar shield, weakening defenses and fueling cognitive decline, but restoring key ...

What if a critical piece of the puzzle of brain aging has been hiding in plain sight? While neuroscience has long focused on ...

Bottlebrush Barrier. The glycocalyx layer (purple, left) that coats brain blood vessels consists of numerous glycoproteins, ...

Researchers reveal that the loss of mucin-type O-glycosylation in the brain endothelial glycocalyx weakens the blood-brain ...

但希望之光已然显现：研究者通过腺相关病毒（AAV）基因治疗，将衰老小鼠脑血管的糖萼厚度恢复83%，不仅逆转血管渗漏，更让20月龄老年鼠在迷宫测试中展现超越年轻组的空间记忆能力。这项颠覆性发现不仅重新定义了血脑屏障的防御机制，更为对抗阿尔茨海默病开辟了 ...

Stanford scientists discovered that sugar chains on brain cells, called the glycocalyx, degrade with age, weakening the blood ...

Protecting the endothelial glycocalyx with a new therapy prevents diabetic microvascular complications, offering a systemic ...

In a study in aging mice, Shi has uncovered striking age-related changes in the sugary coating – called the glycocalyx – on cells that form the blood-brain barrier, a structure that protects ...

Study investigates the sugary-rich layer of the blood brain barrier and the link between its degradation and dementia ...