引言在与癌症的博弈中，研究人员始终在追寻肿瘤细胞的致命弱点。传统T细胞疗法如同精密制导武器，通过识别癌细胞表面的突变抗原来发动攻击，却在实体瘤治疗中屡屡碰壁：肿瘤内部如同错综复杂的迷宫，不同区域的癌细胞携带迥异的基因突变（肿瘤异质性），而低突变负荷的 ...

STX16微缺失仅在母体等位基因上引起假甲状旁腺功能低下- 1b型。在这里，作者表明等位基因特异性致病性反映了决定GNAS印迹的双等位基因活性增强子的不同构象。 双等位基因活性胚胎增强子通过等位基因特异性构象决定 GNAS 印记 在生命科学领域，基因组印记是 ...

Here, the authors show that the allele-specific pathogenicity reflects differential conformations of a biallelically active enhancer dictating GNAS imprinting. Epigenomic and transcriptomic ...

Here, the authors show that the allele-specific pathogenicity reflects differential conformations of a biallelically active enhancer dictating GNAS imprinting. The mechanisms underlying the ...

Accra, Jan. 26, GNA – The Ghana News Agency’s cooperation agreement with the Moroccan Press Agency (MAP) is an impetus for professional development and agency relations, Mr Albert Kofi Owusu, the ...

2 Biomedical Pioneering Innovation Center & Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing, China 3 Peking-Tsinghua Center for Life Sciences, Peking University ...

Genes involved in microbe sensing and inflammatory response are tagged. (H) UMAP projection plots show expression of dopamine synthesis (ddc) and signaling (gnas) genes in GF (left) and CV (right) ...

Background De novo mutations (DNMs) are linked with many severe early-onset disorders ranging from rare congenital malformation to intellectual disability. Conventionally, DNMs are considered to have ...