引言在与癌症的博弈中，研究人员始终在追寻肿瘤细胞的致命弱点。传统T细胞疗法如同精密制导武器，通过识别癌细胞表面的突变抗原来发动攻击，却在实体瘤治疗中屡屡碰壁：肿瘤内部如同错综复杂的迷宫，不同区域的癌细胞携带迥异的基因突变（肿瘤异质性），而低突变负荷的 ...

STX16微缺失仅在母体等位基因上引起假甲状旁腺功能低下- 1b型。在这里，作者表明等位基因特异性致病性反映了决定GNAS印迹的双等位基因活性增强子的不同构象。 双等位基因活性胚胎增强子通过等位基因特异性构象决定 GNAS 印记 在生命科学领域，基因组印记是 ...

Here, the authors show that the allele-specific pathogenicity reflects differential conformations of a biallelically active enhancer dictating GNAS imprinting. Epigenomic and transcriptomic ...

Here, the authors show that the allele-specific pathogenicity reflects differential conformations of a biallelically active enhancer dictating GNAS imprinting. The mechanisms underlying the ...

Accra, Jan. 26, GNA – The Ghana News Agency’s cooperation agreement with the Moroccan Press Agency (MAP) is an impetus for professional development and agency relations, Mr Albert Kofi Owusu, the ...