A vast search of natural diversity has led scientists at MIT's McGovern Institute and the Broad Institute of MIT and Harvard ...

CRISPR technology, driven by Cas9, redefines gene editing, facilitating targeted DNA modifications that advance genetic ...

Recent breakthroughs and regulatory shifts in gene editing might be the key to moving from treating the symptoms of diseases ...

(3) Scientists directly provide the sequence encoding all CRISPR components, a Cas protein and a guide RNA, into the target microbe. (4) Alternatively, scientists co-opt the bacteria’s endogenous ...

This protein can easily be programmed to find and bind to almost any desired target sequence, simply by giving it a piece of RNA to guide it in its search. When the CRISPR Cas9 protein is added to ...

Guided by RNA, the Cas9 endonuclease breaks DNA at ... using adeno-associated virus with transposon-based delivery of the CRISPR guide RNAs. Oliynyk and Church present a protocol for designing ...

A vast search of natural diversity has led scientists at MIT's McGovern Institute and the Broad Institute of MIT and Harvard to uncover ancient ...

One of the barriers to using CRISPR-Cas9 gene editing in the clinic is the possibility ... mutations throughout the genome and show in mice that a carefully designed guide RNA strand does not produce ...

The CRISPR-Cas gene scissors offer a wide range of potential applications, from the treatment of genetic diseases to antiviral therapies and diagnostics. However, to safely harness their powers, ...