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The major histocompatibility complex (MHC) is a cluster of genes encoding molecules that are important for lymphocyte activation. MHC molecules bind small fragments of proteins from inside a cell ...

A bioinformatics best-practice analysis pipeline for epitope prediction and annotation ...

The association of HLA-B35 with ON in this case suggests a potential overlap between systemic autoimmune predispositions and localized inflammatory responses in the optic nerve. This aligns well with ...

Connecting decision makers to a dynamic network of information, people and ideas, Bloomberg quickly and accurately delivers business and financial information, news and insight around the world ...

Major histocompatibility complex class II (MHC-II) is essential for immune surveillance within the TME. While MHC-II genes are typically expressed by professional antigen-presenting cells, they are ...

The prevailing theory, proposed by Cudkowicz, postulated the existence of recessive 'Hh antigens', expressed only by MHC homozygous mice. Because of lack of expression in heterozygotes ...

由于新冠疫情的出现，mRNA疫苗被推上研究热潮，并有越来越多的学者开始关注mRNA疫苗在肿瘤中的治疗作用。此前国外已有研究证明在术后环境中利用个性化疫苗覆盖多种新抗原，并降低肿瘤负荷，是一种实用的mRNA治疗策略。然而，肿瘤疫苗是否可以用于高肿瘤负荷的晚期癌症患者尚不清楚。另外，目前还没有针对单一新抗原的疫苗策略的报道。分析所有已报道的免疫反应性新抗原的未发表数据表明，新抗原在个体之间重叠的比例极 ...

"一针"治愈肿瘤，细胞疗法真有这么神吗？细胞疗法到底进展到什么阶段，是否给所有肿瘤的患者都带来新希望？一文揭秘细胞疗法，帮助大家读懂这一肿瘤创新治疗手段的原理与前景。备受瞩目的CAR-T细胞疗法，因其可以直接特异性识别肿瘤表面抗原，有高效性、靶向性和 ...

However, there are a few risks involved in plasma transfusion; notably, transfusion-related acute lung injury (TRALI) caused by antibodies against human leukocyte antigens (HLA). This study was ...

In this study, we employed all-atom molecular dynamics simulations to investigate the impact of different membrane compositions on the conformational dynamics of the NKG2A/CD94/HLA-E immune receptor ...