HMGB1 that belongs to the High Mobility Group-box superfamily, is a nonhistone chromatin associated transcription factor. It is present in the nucleus of eukaryotes and can be actively secreted or ...

The evolutionarily conserved high mobility group box1 (HMGB1) is a ubiquitous nuclear protein that can be released by almost all cell types. HMGB1 lacks signal peptide and utilizes diverse ...

uhnresearch.ca Objectives We have previously shown that peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor, is essential for the normal growth and development of ...

编者按双环醇（4,4'-二甲氧基-5,6,5',6'-双亚甲二氧基-2-羟甲基-2'-甲氧羰基联苯）是中药五味子的衍生物，近年来在肝病治疗领域展现出了显著的疗效和安全性。随着研究的深入，其应用前景已远远超出了肝脏疾病的范畴。近日，天津医科大学总医院消 ...

College of Food Science and Engineering, Northwest A&F University, Yangling 712100, P. R. China ...

Restoring endothelial SIRT6 function could mitigate experimental HFpEF by suppressing peroxisome proliferator‐activated receptor gamma (PPARγ) expression through the deacetylation of histone H3K9 ...