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解锁整合应激反应:打开神经退行性疾病治疗新大门的关键?
ATF5 对 也有直接影响,抑制其功能会抑制 相关基因的诱导,而过表达 ATF5 则能在缺乏 ATFS - 1 的秀丽隐杆线虫中恢复 HSP60 的表达。这些结果表明,ATF - 5(或其在秀丽隐杆线虫中的异构体 ATFS - 1)在线粒体功能调节中具有双重作用,这一现象还需要进一步深入研究。
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