T cell populations including CD4+ helper T cells, CD8+ cytotoxic T cells and Foxp3+ regulatory T cells play a critical role in controlling or promoting inflammatory disease’s progression. In recent ...
Interaction between genetic factors, estrogen and aging in the development of Th1/TH2 differentiation and subsequent autoimmune diseases in aging women. DC: Dendritic cell; Th: T-helper cell.
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A research team at the University of Konstanz, led by toxicologist Ivano Amelio, has demonstrated how differently individual mutations of the tumour suppressor p53 affect pancreatic carcinomas.
Filamin proteins are degraded by ASB2α E3 ubiquitin ligase and may affect T cell function. Here the authors show that increased levels of Filamin A and Filamin B in Th2 cells reduces allergic ...