Localisation of GDNF was determined by immunohistochemistry (figure 1E) and positive staining was evident in the hepatic sinusoids of patients with mild liver fibrosis. With increasing disease ...

As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

Transplanting insulin-producing cells along with engineered blood-vessel-forming cells has successfully reversed type 1 ...

Blood flows through sinusoidal channels of the liver lobules and drained into central veins. Sinusoidal endothelial cells form the wall of liver sinusoids which play critical roles in liver ...

The morbidity and mortality of hepatic fibrosis caused by various etiologies are high worldwide, and the trend is increasing annually. At present, there is no effective method to cure hepatic fibrosis ...

What Is an Inflamed Liver? Inflammation is the body's way to heal an injury or damaged cells. In the liver, this injury can be caused by many things, including an infection, toxins, or the buildup ...

Cirrhosis is a condition in which scar tissue gradually replaces your healthy liver cells. It usually happens over a long period, often due to hepatitis, alcohol use disorder, or metabolic ...

Objective Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in ...