As noted above, stellate cell activation is the central event in hepatic fibrosis. Activation consists of 2 major phases: (1) initiation (also called apreinflammatory stage) and (2) perpetuation ...

Get Instant Summarized Text (Gist) Lhx2, a transcription factor in hepatic stellate cells, is identified as a key regulator that promotes liver regeneration and inhibits fibrosis. It enhances ...

Activation of hepatic stellate cells is the central event in hepatic fibrosis. These perisinusoidal cells orchestrate an array of changes including degradation of the normal ECM of liver ...

az.vub.ac.be Accumulating evidence suggests that stellate cells are involved in the regulation of the liver microcirculation and portal hypertension. Activated hepatic stellate cells have the ...

Background—The pathogenesis of pancreatic fibrosis is unknown. In the liver, stellate cells (vitamin A storing cells) play a significant role in the development of fibrosis. Aims—To determine whether ...

Liver fibrosis develops from excessive matrix produced by activated hepatic stellate cells (HSCs). Here, authors identify ABHD17B via an siRNA screen and show that ABHD17B regulates the fibrotic ...

Liver lymphatic vessels support liver function by draining interstitial fluid, cholesterol, fat, and immune cells for surveillance in the liver draining lymph node. Chronic liver disease is associated ...

Human hepatocytes derived liver progenitor-like cells (HepLPCs) have been reported as a novel source of liver cells for development of in vitro models, cell therapies, and tissue-engineering ...

The liver is a large internal organ that is under your right ribs just beneath your right lung. It has two lobes (sections). The liver is made up mainly of cells called hepatocytes. It also has other ...

What Is an Inflamed Liver? Inflammation is the body's way to heal an injury or damaged cells. In the liver, this injury can be caused by many things, including an infection, toxins, or the buildup ...