Investigations. Immunohistochemical analysis for DNA mismatch repair proteins, germline mutation analysis of MSH2. Diagnosis. Lynch syndrome with a heterozygous germline mutation in MSH2.
In the end, however, selection constantly sorts through the variation that is produced by mutations to select the fit and remove the unfit, while ignoring neutral changes. A few distinct types of ...
UCSF Benioff Children's Hospital Oakland is enrolling patients in an innovative clinical trial that seeks to cure sickle cell disease. The trial is the first in the U.S. to apply non-viral CRISPR-Cas9 ...