CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...
Casgevy (exagamglogene autotemcel or exa-cel) became the first drug based on the CRISPR/Cas9 gene-editing technology to be approved towards the end of last year, when it was cleared by the FDA for ...
CRISPR-Cas systems are prokaryotic immune systems ... Here, Miskalis et.al. developed SPLICER, a Cas9 base editor toolbox which enhances overall exon skipping efficiency and lowers cryptic ...
Such techniques change the genetic makeup of plants, for example by using CRISPR-Cas9 technology, which can edit the genes of animals ... and "predictability," warning that there remained "many gray ...