Finally, in July 2024, they showed that harmine alone increases human beta cell mass by 300%, and if a GLP-1RA is added, by 700%. A key question has been how harmine causes beta cells to regenerate.

The most complex engineering of human cell lines ever has been achieved by scientists, revealing that our genomes are more resilient to significant structural changes than was previously thought.

Treatment of human T-ALL cell lines harboring activating mutations in NOTCH1 with GSIs abrogates NOTCH1 signaling effectively. However, most of human T-ALL cell lines show no apparent cellular ...

The primary cilia observed in this study originated from both animal and human beta cells. The researchers investigated how ...

Nat Med. 2006;12(3):310-316. In conclusion, our study addresses an important fundamental question about beta-cell regeneration: namely, whether regeneration occurs by replication of preexisting ...