Development of animal models for bone cancer faces another challenge in the accessibility of tumor engraftment sites. Here, we describe a protocol to develop an orthotopic humanized mouse model for a ...

Ray Lambert looks at the potential of humanized FcRn mice for evaluating the pharmacokinetics of mAbs. Due to their extraordinary specificity and pharmacokinetic (PK) behavior, human ...

To circumvent the limitations of available preclinical models for the study of type 1 diabetes (T1D), we developed a new humanized model, the YES-RIP-hB7.1 mouse. This mouse is deficient of murine ...

A new study shows that giving mice the human version of a gene changes their squeak, suggesting some of the genetic ...

A new study shows that giving mice the human version of a gene changes their squeak, suggesting some of the genetic ...

"The quality and quantity of the chirping was distinctly different in the humanized mice," says Darnell. And genetically altered adult males sang notably different romantic songs. "They mix it up ...

“This is the first mouse model with truly humanized telomeres because telomerase isn’t expressed in adult tissues in this model,” Zhu said. “Our paper demonstrates that they exhibit human ...