The deficiency of 21-hydroxylase due to CYP21A2 pathogenic variants is a rather frequent disease with serious consequences, going from a real mortality risk to infertility and to milder symptoms, ...

Institute of Pharmaceutical Sciences, University of Freiburg, Freiburg 79104, Germany ...

A breakthrough study has uncovered a hidden player in Parkinson’s disease—24-OHC, a cholesterol metabolite that fuels the ...

Researchers suggest drugs that prevent cholesterol from being converted to 24-OHC might therefore be an effective treatment for Parkinson's disease.

We investigated the role of dopamine beta-hydroxylase (DBH) gene polymorphisms on pain variability in SCD. DBH is a key enzyme in the catecholamine biosynthesis pathway that catalyzes the conversion ...

Researchers led by Zhentao Zhang at Wuhan University, China have discovered a cholesterol metabolite that plays a critical ...

A groundbreaking study by researchers at Wuhan University, China, has identified a cholesterol metabolite that plays a ...

State of New Jersey Common Pension Fund D raised its stake in BridgeBio Pharma, Inc. (NASDAQ:BBIO – Free Report) by 21.6% ...

Researchers led by Zhentao Zhang at Wuhan University, China have discovered a cholesterol metabolite that plays a critical ...

以前，我们对 STN - DBS 潜在的神经保护作用只是猜测，现在研究人员通过实验证实了它在减少 TrkB 簇形成和保护多巴胺能神经元方面的作用。这不仅让我们对大脑中复杂的神经调节机制有了更深入的了解，也为未来开发更有效的帕金森病治疗方法提供了重要线索。比如，我们可以根据这些发现，进一步优化 STN - DBS 的治疗方案，找到最佳的刺激参数，提高治疗效果。而且，TrkB ...

Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States ...