"Intriguingly, under normal oxygen levels in the body, called normoxia, IFN-g induction and glycolysis in T cells are not mediated by HIF1α, a primary regulator of glycolysis, but by its widely ...

The regulator HIF1α functions in a cancer-microenvironment that lacks oxygen, and it may be involved in resistance to immune ...

For years, scientists have looked to a critical piece of immune system machinery - known as the interferon pathway - for answers. There, when our cells sense an infection, they release a protein known ...

Researchers have discovered a protein variant that serves as a knob for regulating the body's innate immune response. The findings could lead to new therapies for Long COVID, autoimmune disorders, and ...

Researchers have shown how genetic defects in Toxoplasma gondii are rescued if co-infected with normal parasites, thanks to supportive secreted proteins.

WASHINGTON — Children who have systemic juvenile idiopathic arthritis with lung disease (sJIA-LD) have distinct biomarker ...

Cancer cells impair monocyte-mediated T-cell activation by disrupting inflammatory pathways in the tumor microenvironment.

Deuruxolitinib showed significant efficacy and safety in hair regrowth stimulation among adult patients with alopecia areata, ...

However, many of these species have become infected by the virus. This study investigated the conservation of 24 host protein targets, including the entry proteins ACE2 and transmembrane serine ...

Here the authors use a pre-clinical model of chronic experimental asthma to show that corticosteroids suppress endogenous PGD2 and IFN-γ production, necessary for the beneficial effects of DP2 ...

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, USA Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, USA Department of ...