IGF1, IGF2 and insulin act primarily through tyrosine-kinase-linked receptors—the IGF1 receptor (IGF1R) and insulin receptor (IR). The IGF1R binds IGF1 and IGF2 with high affinity and the IR ...

研究人员们巧妙地利用荧光共振能量转移（FRET, Fluorescence resonance energy ...

NT219, a novel agent designed to overcome tumor resistance to drug therapy, will be evaluated in combination with the ...

Israel-based clinical-stage company Purple Biotech today announced it is advancing into a Phase II study with NT219 in ...

研究人员为探究脊髓损伤（SCI）后小胶质细胞与可塑性的关系，用单细胞 RNA 测序研究，发现小胶质细胞状态随时间和 LPS 注射改变，为 SCI 治疗提供新思路。 单细胞 RNA 测序（single-cell RNA sequencing，scRNAseq） ：通过该技术对不同阶段（亚急性期和慢性期）、不同处理（注射 LPS ...

Purple Biotech’s NT219 is a first-in-class small molecule drug designed to target key cancer resistance mechanisms by degrading IRS1/2 and blocking IGF1R/IRS1 and STAT3 survival pathways ...

Antibodies and related products are the fastest growing class of therapeutic agents. By analysing the regulatory approvals of IgG-based biotherapeutic agents in the past 10 years, we can gain ...

1 Department of Clinical Oncology, The University of Hong Kong, Hong Kong, China 2 Center for Cancer Research, The University of Hong Kong, Hong Kong, China 3 Department of Surgery, The University of ...

Discover how cutting-edge single-nucleus multi-omics reveals the secrets of ovarian aging, paving the way for breakthroughs in fertility and health longevity. Study: Molecular and genetic insights ...

This adjustment followed Acelyrin's recent unveiling of Phase 3 LONGITUDE program's trial design for lonigutamab, an anti-IGF1R treatment for Thyroid Eye Disease (TED) patients. Despite some ...