Control systems are ubiquitous in modern day technology. In industrial contexts, these systems ensure that relevant variables ...

This manuscript provides fundamental studies to help us better understand the effects of mutations in the presenilin-1 (PSEN1) gene on proteolytic processing of the amyloid precursor protein (APP).

The culture was diluted 1:20 and grown until OD600nm reached 0.4 to 0.6. It was then diluted in Mg-Terrific broth to an OD600nm of 0.01 and induced with IPTG to a final concentration of 5 mM for 16 h.

Among the single exchanges, substitution of the hydrophobic phenylalanine residue at position 2 (F2Y and F2E) led to a disperse or, occasionally, patchy distribution of the fusion protein (Figure 1B .