in vitro and cell assays the researchers discovered that the IgG Fc domain, specifically CH3, interacts with the insulin receptor (IR) to impede insulin signaling. IgG binds to IR with a KD of ...

This review summarizes recent progress in both natural and engineered structural modifications of IgG antibodies, including allotypic variation, glycosylation, Fc engineering, and Fc gamma receptor ...

In obesity, B cells accumulate in white adipose tissue (WAT) and produce IgG, which may contribute to the development of glucose intolerance. IgG signals by binding to Fcγ receptors (FcγR ...

TLRs critically link innate immunity to adaptive immunity by regulating the activation of antigen-presenting cells and key cytokines. Furthermore, recent studies also have shown that TLR signaling can ...

BCR signaling plays a crucial role in the pathogenesis of CLL. 2,9,10 Activation of this pathway fosters an ideal leukemic microenvironment, promoting CLL cell proliferation and survival. 2 BCR ...

This valuable work presents how PRDM16 plays a critical role during colloid plexus development, through regulating BMP signaling. Solid evidence supports the context-dependent gene regulatory ...

13, 2025 — Study participants who went on an IgG-based elimination ... have found a new receptor for nerve growth factor that plays an important role in pain signaling, even though it does ...

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X-linked myopathy with excessive autophagy (XMEA) is a rare disease for which pre-clinical models lack, challenging the ...

Ray Lambert looks at the potential of humanized FcRn mice for evaluating the pharmacokinetics of mAbs. Due to their extraordinary specificity and pharmacokinetic (PK) behavior, human ...

While the exterior of vertebrate bodies appears bilaterally symmetrical, internal organ positioning and morphology frequently exhibit left-right (L-R) asymmetries. In several vertebrates, including ...