Of these epigenetically labile targets, the transposable elements and imprinted genes are particularly important. Transposable elements and metastable epialleles. Most regions of the adult ...

CRISPR epigenome editing successfully reactivates silenced genes in Prader-Willi Syndrome, highlighting potential for ...

This significant breakthrough was achieved by overcoming imprinting gene challenges through 20 specific genetic modifications. While the mice survived to adulthood, they exhibited health issues ...

1994a,b) causing dramatic changes of allele frequencies for growth genes between breeds, which would enable detection of more growth QTL compared with QTL influencing composition in the breed-cross ...

Sexual reproduction in mammals is a complex process. It involves a balance between the genetic material of both parents. A crucial mechanism, called genetic imprinting, plays a key role in this ...

The work has been reported in Cell Stem Cell. Gene imprinting refers to a process in which cells either express a gene from one parent, while the copy of that gene that is inherited from the other ...

A crucial mechanism, called genetic imprinting, plays a key role in this process. Certain genes, known as "imprinted genes," are activated or deactivated depending on whether they are inherited ...

The latest advancement was made possible through the precise genetic engineering of imprinted genes, which are typically expressed from only one parental copy, while the other copy is silenced ...

In a world-first, scientists in China have successfully created mice with two biological fathers. The mice not only survived birth but grew into adulthood, marking a significant step in understanding ...

In the new study, mice were created through genetic editing of mouse embryonic stem cells targeting a class of mammal-specific genes known as imprinted genes, of which there are about 200, the ...

Gene silencing is a negative feedback mechanism that regulates gene expression to define cell fate and also regulates metabolism and gene expression throughout the life of an organism. In plants, gene ...