The regulator HIF1α functions in a cancer-microenvironment that lacks oxygen, and it may be involved in resistance to immune ...

Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their effectiveness has ...

In an interview, Vincent Law, of Moffitt Cancer Center, discussed a new study that offers hope for patients with melanoma ...

July 22, 2024 — The effectiveness of CAR T cell therapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for ...

Prostate cancer and other cancers characterized by “cold” tumors could become more responsive to checkpoint blockade if UBA1 is inhibited.

A study from the University of Michigan Health Rogel Cancer Center may have—at last—cracked the cold case of immunotherapy ...

T cells are white blood cells that are important for adaptive immunity. They have unique cell surface receptors that are generated by randomly assorting genes. These receptors allow T cells to ...

Inhibiting its activity increases T-cell recruitment and lowers tumor ... looking at more than 600 genes and their correlation with interferon-gamma, an anti-tumor gene that immune effector ...

Inhibiting its activity increases T-cell recruitment and lowers tumor resistance to immunotherapies ... The researchers analyzed genetic data from 208 metastatic prostate tumor samples, looking at ...