Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their effectiveness has ...

The regulator HIF1α functions in a cancer-microenvironment that lacks oxygen, and it may be involved in resistance to immune ...

Researchers have shown how genetic defects in Toxoplasma gondii are rescued if co-infected with normal parasites, thanks to ...

Based on more than six months of additional monitoring, data show continued improvement in overall survival (OS) in intent-to-treat (ITT) ...

Prostate cancer and other cancers characterized by “cold” tumors could become more responsive to checkpoint blockade if UBA1 is inhibited.

A study from the University of Michigan Health Rogel Cancer Center may have—at last—cracked the cold case of immunotherapy ...

Inhibiting its activity increases T-cell recruitment and lowers tumor resistance to immunotherapies ... The researchers analyzed genetic data from 208 metastatic prostate tumor samples, looking at ...

In August 2024, the company expects to file a supplemental Biologics License Application for tafasitamab for the treatment of patients with FL who have failed at least one prior systemic anti-CD20 ...

Cytotoxic T cells are CD8-postive T cells that are specialized for the direct killing of cells that are infected (particularly with viruses), cancerous or damaged in other ways. They express the ...

This image provided by Ana-Maria Cujba shows blood vessels in a portion of the human small intestine, March 21, 2024. (Ana-Maria Cujba/Wellcome Sanger Institute via AP) This image provided by Nathan ...

Scientists can "poke the cells, perturb the cells" in ways that wouldn't be possible in human subjects, she said. Thus, making true-to-life organoids can help reveal how diseases arise and which ...