In the present study, we show that systemic administration of β-glucan reprograms alveolar macrophages (AMs) in the lung via neutrophils and IFNγ signalling, in a Dectin1-independent manner. We ...

Furthermore, we show that N-terminal residues 1 to 130 in TRPV4 is essential in suppression of miR-146a expression in LPS-stimulated macrophages. Altogether, this study identifies a regulatory ...

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Anti-Inflammatory Effects Basic Experiments in Mice Macrophage Activating Factor markedly suppressed TNF-α and IL-1β production in response to LPS in both in vivo and in vitro studies involving ...

The findings are significant for the liver research community and others interested in the gut-liver axis. (A) AOAH cleaves the two piggyback fatty acyl chains from the lipid A moiety, inactivating ...

Mechanical control is fundamental for cellular localization within a tissue, including for tumor-associated macrophages (TAMs). While the innate immune sensing pathways cGAS-STING and RLR-MAVS impact ...

The underlying regulatory mechanisms of metabolic switching are assessed by both in vitro and in vivo studies. Conclusions Selectively modulating the ‘context’ of glycolytic macrophages in HCC tumours ...

Intestinal resident macrophages play an important role in the pathogenesis and progress of IBD, as well as in maintaining intestinal homeostasis and facilitating tissue repair. This review delves into ...

A team of Indian researchers has highlighted the therapeutic properties of Candy Leaf, or Stevia rebaudiana, beyond its ...

Scientists at Trinity College Dublin have discovered a new process in our immune systems that leads to the production of an ...