Scientists at Trinity College Dublin have discovered a new process in our immune systems that leads to the production of an ...

The findings are significant for the liver research community and others interested in the gut-liver axis. (A) AOAH cleaves the two piggyback fatty acyl chains from the lipid A moiety, inactivating ...

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In the present study, we show that systemic administration of β-glucan reprograms alveolar macrophages (AMs) in the lung via neutrophils and IFNγ signalling, in a Dectin1-independent manner. We ...

The Krebs cycle byproduct itaconate has recently emerged as an important metabolite regulating macrophage immune functions, but its role in tumor cells remains unknown. Here, we show that increased ...

Both M1-like and M2-like TAMs have distinct cell surface markers and functional factors. M1-like TAMs are induced by interferon-γ (IFN-γ), lipopolysaccharides (LPS) and tumor necrosis factor-α (TNF-α) ...

Furthermore, we show that N-terminal residues 1 to 130 in TRPV4 is essential in suppression of miR-146a expression in LPS-stimulated macrophages. Altogether, this study identifies a regulatory ...

Anti-Inflammatory Effects Basic Experiments in Mice Macrophage Activating Factor markedly suppressed TNF-α and IL-1β production in response to LPS in both in vivo and in vitro studies involving ...

Mechanical control is fundamental for cellular localization within a tissue, including for tumor-associated macrophages (TAMs). While the innate immune sensing pathways cGAS-STING and RLR-MAVS impact ...