USA: Research shows that the melanocortin-4 receptor (MC4R) agonist setmelanotide effectively lowers BMI in children with ...

Cholesterol restriction-mediated SREBP1 activation induces noncanonical type I IFNs, including IFN-ω and minor IFN-α subsets, ...

During your time with Pathways to Medicine, you will participate in events and activities throughout Year 12 and 13. Every aspect of the programme is designed to help you make a strong and informed ...

However, its precise pathogenesis remains elusive. Consequently, researchers are dedicated to uncovering CI-AKI’s pathophysiology and signaling pathways, including inflammation, oxidative stress, ...

But in some individuals with obesity, this signaling system seems to malfunction—a condition known as leptin resistance, where high levels of leptin fail to curb hunger.

A key function of IRS proteins in peripheral tissues is to couple insulin receptor activation to signaling via the PI3K signal transduction pathway, and in neurons, PI3K is implicated as a key ...

For example, when people have a mutation in the leptin receptor in the hypothalamus, or they have one of those peptides in the signaling pathway of leptin or melanocortin 4 receptors impairment ...

These effects are mediated by the activation of the MC4R-cAMP-GLP-1 signaling pathway, highlighting the importance of this molecular pathway in the regulation of glucose metabolism. Furthermore, we ...

2021). In short, pathway abundances are computed on community level as well as for individual taxa based on the abundances of the individual component reactions constituting an entire pathway. The ...

In 2020, researchers from institutes in Germany and Greece reported a mechanism in the brain's outer cortical cells that produces a novel 'graded' signal all on its own, one that could provide ...

Tropical Cyclone Wind Signal (TCWS) No. 3 was raised over three areas early Monday as Typhoon Pepito (international name: Man-Yi) moves over the West Philippine Sea, PAGASA said in its bulletin. TCWS ...