USA: Research shows that the melanocortin-4 receptor (MC4R) agonist setmelanotide effectively lowers BMI in children with ...

Cholesterol restriction-mediated SREBP1 activation induces noncanonical type I IFNs, including IFN-ω and minor IFN-α subsets, ...

During your time with Pathways to Medicine, you will participate in events and activities throughout Year 12 and 13. Every aspect of the programme is designed to help you make a strong and informed ...

However, its precise pathogenesis remains elusive. Consequently, researchers are dedicated to uncovering CI-AKI’s pathophysiology and signaling pathways, including inflammation, oxidative stress, ...

But in some individuals with obesity, this signaling system seems to malfunction—a condition known as leptin resistance, where high levels of leptin fail to curb hunger.

For example, when people have a mutation in the leptin receptor in the hypothalamus, or they have one of those peptides in the signaling pathway of leptin or melanocortin 4 receptors impairment ...

These effects are mediated by the activation of the MC4R-cAMP-GLP-1 signaling pathway, highlighting the importance of this molecular pathway in the regulation of glucose metabolism. Furthermore, we ...

In 2020, researchers from institutes in Germany and Greece reported a mechanism in the brain's outer cortical cells that produces a novel 'graded' signal all on its own, one that could provide ...

Tropical Cyclone Wind Signal (TCWS) No. 3 was raised over three areas early Monday as Typhoon Pepito (international name: Man-Yi) moves over the West Philippine Sea, PAGASA said in its bulletin. TCWS ...

Officials from DCR and Boston said there will be signal and infrastructure changes coming to the bridge this fall, including updated traffic signaling and lane changes. Peter Furth, the co-founder ...

Tropical Cyclone Wind Signal (TCWS) No. 4 was raised over three areas in Luzon as Ofel weakened into a typhoon after making landfall in Baggao, Cagayan on Thursday afternoon, state weather bureau ...

However, in obesity, leptin's transport to the brain is often blocked, leading to leptin resistance. This resistance complicates leptin's utility as a therapeutic agent due to dysfunctional signaling ...