A key novel finding is the discovery that only AMKL cells with high PRMT1 expression drive leukemogenesis, and this PRMT1-driven leukemia can be effectively treated with the PRMT1 inhibitor MS023. The ...

BESREMi is a preferred, FDA-approved option for both symptomatic low- and high-risk polycythemia vera patients. In the polycythemia vera space, BESREMi faces competition from drugs like ruxolitinib, a ...

While research has primarily focused on identifying intrinsic mutations driving leukemogenesis, the role of the bone marrow microenvironment (BMME) in disease progression remains poorly understood.

As mutated NPM1 (mNPM1) drives leukemogenesis through menin and the efficacy of menin inhibitors in producing treatment responses in mNPM1-associated AML, combination therapy using a VISTA ...

Figure 1: Pathological findings and flow cytometric analysis of lymphoma cells in Tax transgenic mice.

Induced pluripotent stem cells (iPSCs) originate from the reprogramming of adult somatic cells using four Yamanaka transcription factors. Since their discovery, the stem cell (SC) field achieved ...

1Anhui Provincial Clinical Research Center for Hepatobiliary Diseases, Hefei, China. 2Department of Hepatobiliary Surgery,Centre for Leading Medicine and Advanced Technologies of IHM, The First ...

Enzootic Bovine Leukosis (EBL), is infectious disease affecting especially older animals, although animals of all ages can be infected with the Bovine Leukemia Virus (BLV). Crioula Lageana is a ...

Objectives Recently, necroptosis has attracted increasing attention in arthritis research; however, it remains unclear whether its regulation is involved in osteoarthritis (OA) pathogenesis. Since ...