That difference is actually a survival benefit: The combination of two individuals' different MHC (major histocompatibility locus) genes gives their offspring an advantage in beating back disease ...

Researchers from Children's Hospital of Philadelphia (CHOP) and Stanford University have revealed the molecular structure of TRACeR-I, a protein platform for reprogramming immune responses. A better ...

The major histocompatibility complex (MHC) is a cluster of genes encoding molecules that are important for lymphocyte activation. MHC molecules bind small fragments of proteins from inside a cell ...

When these two related strains are intercrossed to elucidate the chromosomal locations of diabetes susceptibility genes, homozygous expression of the NOD MHC alleles is essential for disease ...

In functional analysis, we have studied the roles of the nonclassical MHC class I genes HLA-E, F, and G in immunity. A major recent focus has been on understanding HLA-F function, revealing new ...